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Lupusis a chronic, autoimmune disease and affects a wide part of the body, including the joints, kidneys, skin, blood, brain and other organs. One of our six Delivering on Discovery projects focuses on Lupus and lung disease. “Lupus is a complex disease. It affects many organs. The number of lupus patients with lung inflammation is probably underestimated. Yet it negatively impacts the quality of life in these patients,” explained Dr. Caroline Jefferies. “And while we have a basic understanding about how lupus affects various organs, we need to better understand how it affects the lungs to better manage and treat it.”
Dr. Jefferies is focusing on the lungs with her 3-year Arthritis Foundation-funded project, “Inflammatory neutrophils in lupus lung disease – novel cellular target”。
Continue readingResearchers on the Path to a Cure – Spotlight on Dr. Caroline Jefferies→
为什么我的免疫系统攻击我的关节?原因是什么?If you haverheumatoid arthritis (RA)，这可能是你在某个时候想知道的。爱德华·多尔蒂(Edward Doherty)博士也对此感到好奇，目前正在研究。Dr. Doherty and his co-investigator, Dr. Pathricia Tilstam are studying key cells that drive inflammation in their 2-yearArthritis Foundation-funded project, “MIF/CD74 signaling as a new candidate for immunotherapy of rheumatoid arthritis”。对于类风湿性关节炎这样的自身免疫性疾病，某些东西会触发免疫系统失灵，攻击健康细胞，导致炎症和疾病。多尔蒂博士和蒂尔斯塔姆博士正在寻找一些触发因素，以帮助开发更有效的治疗方法来阻止病情发展和关节破坏。
Continue readingResearchers on the Path to a Cure – Spotlight on Dr. Edward Doherty→
Chances are you haven’t heard of COPA syndrome. That’s because it wasn’t identified as a form of arthritis until 2015. So, what is COPA syndrome? It is a rare, inherited autoimmune disease that is caused by mutation of the COPA gene. It usually appears in early childhood. Patients show symptoms of severe lung disease and arthritis.
Dr. Jordan Orange was one member of a large research team that first identified COPA syndrome in 2015. The team’s published work inNature Geneticswon the Arthritis Foundation’s2015 Howley Award prizefor significantly advancing the understanding of an arthritis-related disease.
Continue readingResearchers on the Path to a Cure – Spotlight on Dr. Jordan Orange→
As an organization, we have always supported and encouraged the active involvement of patients in their own care. Patient perspectives matter greatly when it comes to decisions being made about health care. Their voices are vital in the clinical research process as new medications are being developed and tested.
Patient perspectives play a large role in Dr. Nora Singer’s 3-year Arthritis Foundation-funded project – “Cell-based therapy in systemic onset JIA (sJIA) refractory to conventional “c” and biological “b” DMARDs”。她的项目使用来自成人细胞的干细胞，旨在“重置”免疫系统。The study will compare the safety and effectiveness of the stem cell treatment to conventional and biologicaldisease-modifying antirheumatic drugs (DMARDs). Currently, stem cell therapy is experimental in the U.S. and regulated by the U.S. Food and Drug Administration (FDA), but is less regulated in other countries.
Continue readingResearchers on the Path to a Cure – Spotlight on Dr. Nora Singer→
“You are what you eat” is a phrase we often hear. But how true is it? Dr. Richard F. Loeser, Jr. and his research team are looking at the role of diet in their Arthritis Foundation-funded project “The Role of the Microbiome in MetabolicOsteoarthritis (OA)”。
Different factors play into why a person develops OA, including aging, injury, and being overweight.Diet plays an important role. What you eat can help influence what bacteria (or microbiota) live in your digestive track (gut). This, in turn, can influence what chemicals are released into your body. A healthy gut generally has a more diverse collection of helpful microbiota, while a microbial imbalance can lead to disease.
Continue readingResearchers on the Path to a Cure – Spotlight on Dr. Richard F. Loeser, Jr→
Big things come in small packages, and Dr. Hongsik Cho is very familiar with this phenomenon. When wefirst introduced Dr. Cho in August 2016, he was beginning work on his 2-year Arthritis Foundation-funded project, “A Novel Method of Detecting and Treating Early PTOA Using Smart Nanosome”。他和他的团队正在研究两件事:一种新药和一种新的药物传递系统。这种药物被称为tppa -1，用于预防创伤后骨关节炎(PTOA)引起的炎症。这种药物传递系统使用一种叫做纳米小体的小包，其中含有TPCA-1和一种荧光染料，一旦注入小鼠体内，就会照亮纳米小体的路径。
Continue readingResearchers on the Path to a Cure – Spotlight on Dr. Hongsik Cho→
