Tag Archives: rheumatoid arthritis treatment

rheumatoid arthritis treatment to prevent joint deformities

Aggressive RA Treatment May Prevent Joint Deformities

Thanks to earlier diagnosis and more effective treatments, joint deformities in people withrheumatoid arthritis (RA)are becoming less frequent and severe.

What Causes Joint Deformities in RA?

在受类风湿性关节炎影响的关节中,免疫系统的炎症细胞聚集在关节内壁(称为滑膜),形成异常组织的纤维层(称为脂膜)。pannus释放的物质会加速骨侵蚀,软骨破坏和周围韧带的损伤。受累的关节会失去形状和排列,导致畸形。严重的畸形会导致关节功能丧失,需要进行关节置换手术。

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Future Rheumatoid Arthritis Therapy: Nerve Stimulation

New research suggests that electrical impulses may one day be used to treatrheumatoid arthritis (RA).

Neurosurgeon Kevin J. Tracey, MD, president and CEO of the Feinstein Institute for Medical Research in Manhasset, N.Y., discovered that stimulating the vagus nerve, which extends from the brain stem to the stomach, could control the inflammation that is central to RA.

In healthy people, the nervous system, including the vagus nerve, maintains key bodily functions within a safe zone. One of the vagus nerve’s jobs is to control the production of tumor necrosis factor (TNF), a molecule that triggers inflammation. But in people with RA, the vagus nerve doesn’t keep TNF levels within the safe zone.

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Jakinibs Rheumatoid Arthritis Treatment

Will Jakinibs Change Your Rheumatoid Arthritis Treatment?

An emerging class of medications called janus kinase inhibitors (JAK inhibitors, orjakinibs) is offering new hope to patients withrheumatoid arthritis(RA) who don’t find relief with other treatments.

What are Jakinibs?

Jakinibs are a new class of medication, sometimes called oral biologics. The word “biologic” is misleading, however, because jakinibs work in an entirely different way than the biologics that have been used to date. Jakinibs are small molecules that workinsidecells. Traditional biologics such as etanercept (Enbrel), adalimumab (Humira), abatacept (Orencia) and Infliximab (Remicade) block pro-inflammatory cytokines fromoutside.

Jakinibs are taken by mouth. Traditional biologics are given through infusions or injections.

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